2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Drug Metabolite

Drug Metabolite

Drug Metabolite

Related Products

PDF 3.95 MB

Drug metabolite results when a drug is metabolized into a modified form which continues to produce effects. Drug metabolism redox reactions such as heteroatom dealkylations, hydroxylations, heteroatom oxygenations, reductions, and dehydrogenations can yield active metabolites, and in rare cases even conjugation reactions can yield an active metabolite.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0794BR
    AZ7550 Mesylate (Standard)
    AZ7550 Mesylate (Standard) is the analytical standard of AZ7550 Mesylate. This product is intended for research and analytical applications. AZ7550 Mesylate is an active metabolite of AZD9291 and inhibits the activity of IGF1R with an IC50 of 1.6 μM.
    AZ7550 Mesylate (Standard)
  • HY-W012308
    2′-Hydroxydihydrochalcone
    2′-Hydroxydihydrochalcone (Compound 2a) is an anti-inflammatory agent. 2′-Hydroxydihydrochalcone can be synthesized from the reduction of Flavone (HY-N2424).
    2′-Hydroxydihydrochalcone
  • HY-W011235S
    Norfluoxetine-d5 hydrochloride
    		99.57%
    Norfluoxetine-d5 (hydrochloride) is deuterium labeled 3-Phenyl-3-(4-(trifluoromethyl)phenoxy)propan-1-amine hydrochloride.
    Norfluoxetine-d<sub>5</sub> hydrochloride
  • HY-12388AR
    N-Desmethyl clomipramine hydrochloride (Standard)
    N-Desmethyl Clomipramine (hydrochloride) (Standard) is the analytical standard of N-Desmethyl Clomipramine (hydrochloride). This product is intended for research and analytical applications. N-Desmethyl Clomipramine hydrochloride (Desmethylclomipramine hydrochloride) is a primary plasma N-desmethyl metabolite of Clomipramine. Clomipramine is a tricyclic antidepressant.
    N-Desmethyl clomipramine hydrochloride (Standard)
  • HY-B1986S
    p,p'-DDE-d8
    p,p'-DDE-d8 is the deuterium labeled p,p'-DDE. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM.
    p,p'-DDE-d<sub>8</sub>
  • HY-N11677
    7-Hydroxy-TSU-68
    7-Hydroxy-TSU-68 is a derivative of TSU-68 (HY-10517). It is a metabolite of the biotransformation pathway of TSU-68 in human liver microsomes. The content represents the self-induced hydroxylation level of TSU-68.
    7-Hydroxy-TSU-68
  • HY-W701743
    3,4-Dihydroxyamphetamine hydrochloride
    3,4-Dihydroxyamphetamine (α-Methyldopamine) (hydrochloride) is a secondary metabolite of 3,4-Methylenedioxymethamphetamine (MDMA). 3, 4-dihydroxyamphetamine (hydrochloride) is cytotoxic to rat hepatocytes. 3, 4-dihydroxyamphetamine (hydrochloride) is also used in the study of high blood pressure.
    3,4-Dihydroxyamphetamine hydrochloride
  • HY-143984S
    Minodronic acid impurity 2-d4
    Minodronic acid impurity 2-d4 is the deuterium labeled Minodronic acid impurity 2.
    Minodronic acid impurity 2-d<sub>4</sub>
  • HY-A0115R
    Ramiprilat (Standard)
    Alvimopan (dihydrate) (Standard) is the analytical standard of Alvimopan (dihydrate). This product is intended for research and analytical applications. Alvimopan dihydrate (ADL 8-2698 dihydrate) is a potent, selective, orally active and reversible μ-opioid receptor antagonist, with an IC50 of 1.7 nM. Alvimopan dihydrate has selectivity for μ-opioid receptor (Ki=0.47 nM) over κ- and δ-opioid receptors (Kis=100, 12 nM, respectively). Alvimopan dihydrate can be used for the research of postoperative ileus.
    Ramiprilat (Standard)
  • HY-125780R
    5-Phenylhydantoin (Standard)
    Dasatinib (monohydrate) (Standard) is the analytical standard of Dasatinib (monohydrate). This product is intended for research and analytical applications. Dasatinib (BMS-354825) monohydrate is a highly potent, ATP competitive, orally active dual Src/Bcr-Abl inhibitor with potent antitumor activity. The Kis are 16 pM and 30 pM for Src and Bcr-Abl, respectively. Dasatinib monohydrate inhibits Bcr-Abl and Src with IC50s of <1.0 nM and 0.5 nM, respectively. Dasatinib monohydrate also induces apoptosis and autophagy.
    5-Phenylhydantoin (Standard)
  • HY-109564R
    5α-Pregnane-3β,6α-diol-20-one (Standard)
    Arjungenin (Standard) is the analytical standard of Arjungenin. This product is intended for research and analytical applications. Arjungenin, a triterpene isolated from Terminalia arjuna, is an insect feeding-deterrent and growth inhibitor.
    5α-Pregnane-3β,6α-diol-20-one (Standard)
  • HY-148053R
    Rezivertinib analogue 1 (Standard)
    Rezivertinib analogue 1 (Standard) is the analytical standard of Rezivertinib analogue 1. This product is intended for research and analytical applications. Rezivertinib analogue 1 is a process impurity of osimertinib mesylate. Rezivertinib analogue 1 can be used in the study of non-small cell lung cancer[1].
    Rezivertinib analogue 1 (Standard)
  • HY-155385
    10-Oxo-12(Z),15(Z)-octadecadienoic acid
    10-Oxo-12(Z),15(Z)-octadecadienoic acid is a gut microbial fatty acid metabolite.
    10-Oxo-12(Z),15(Z)-octadecadienoic acid
  • HY-133092R
    Perphenazine sulfoxide (Standard)
    Perphenazine sulfoxide (Standard) is the analytical standard of Perphenazine sulfoxide. This product is intended for research and analytical applications. Perphenazine sulfoxide is a sulphoxide metabolite of Perphenazine, formed by the oxidation of Perphenazine.
    Perphenazine sulfoxide (Standard)
  • HY-133005
    Desacetylvinblastine
    Desacetylvinblastine (4-Desacetylvinblastine) is the major metabolite of Vinblastine (HY-13780) and a cytotoxic agent. When used alone, desacetylvinblastine has poor anti-tumor effects, but it can exert significant anti-tumor activity when in the presence of specific conjugates.
    Desacetylvinblastine
  • HY-144242S
    Voriconazole EP impurity D-d3
    Voriconazole EP impurity D-d3 is the deuterium labeled Voriconazole EP impurity D.
    Voriconazole EP impurity D-d<sub>3</sub>
  • HY-W706930
    DCBA-d10
    DCBA-d10 is the deuterium labeled DCBA (HY-136612). DCBA is a metabolite of insect repellent N-N-diethyl-meta-toluamide (DEET). The concentration of DCBA in urine can assess exposure to DEET.
    DCBA-d<sub>10</sub>
  • HY-W766709
    Desdiacetyl bisacodyl-d13
    Desdiacetyl bisacodyl-d13 is the deuterium labeled Desacetyl bisacodyl (HY-131637). Desacetyl bisacodyl is the active metabolite of the laxative bisacodyl. Desacetyl bisacodyl induces epithelial Cl(-) secretion in rat colon and rectum. Desacetyl bisacodyl evokes several effects at the colon or rectum, including increased mucus and chloride secretion.
    Desdiacetyl bisacodyl-d<sub>13</sub>
  • HY-136498AR
    T-705RMP ammonium (Standard)
    Rilmenidine (phosphate) (Standard) is the analytical standard of Rilmenidine (phosphate). This product is intended for research and analytical applications. Rilmenidine phosphate, an innovative antihypertensive agent, is an orally active, selective I1 imidazoline receptor agonist. Rilmenidine phosphate is an alpha 2-adrenoceptor agonist. Rilmenidine phosphate induces autophagy. Rilmenidine phosphate acts both centrally by reducing sympathetic overactivity and in the kidney by inhibiting the Na+/H+ antiport. Rilmenidine phosphate modulates proliferation and stimulates the proapoptotic protein Bax thus inducing the perturbation of the mitochondrial pathway and apoptosis in human leukemic K562 cells .
    T-705RMP ammonium (Standard)
  • HY-12784AS1
    Cycloguanil-d6 hydrochloride
    Cycloguanil-d6 hydrochloride is the deuterium labeled Cycloguanil hydrochloride. Cycloguanil hydrochloride, the active metabolite of Proguanil, acts on malaria schizonts in erythrocytes and hepatocytes.
    Cycloguanil-d<sub>6</sub> hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity